{"id":6382,"date":"2024-04-18T03:19:01","date_gmt":"2024-04-18T03:19:01","guid":{"rendered":"https:\/\/jobelyn.com.ng\/ng\/?p=6382"},"modified":"2024-04-18T03:19:01","modified_gmt":"2024-04-18T03:19:01","slug":"sorghum-grain-polyphenol-for-anti-inflammatory-cytokines-tnf-a-il-6","status":"publish","type":"post","link":"https:\/\/jobelyn.com.ng\/ng\/2024\/04\/18\/sorghum-grain-polyphenol-for-anti-inflammatory-cytokines-tnf-a-il-6\/","title":{"rendered":"Sorghum grain Polyphenol for Anti-inflammatory Cytokines TNF-a &#038; IL-6"},"content":{"rendered":"<p>&nbsp;<\/p>\n<ol>\n<li>FROM NATIONAL CANCER INSTITUTE WEBSITE8<\/li>\n<\/ol>\n<h1 class=\"dictionary-definiton__term-title\" data-cdr-id=\"752436\">Sorghum bicolor supplement<\/h1>\n<div class=\"dictionary-definiton__term-definition\">\n<div class=\"dictionary-definiton__definition\">An herbal-based nutritional supplement containing the leaf sheaths of the plant Sorghum bicolor, with potential antioxidant, anti-inflammatory, chemopreventive and immunomodulating activities. Sorghum bicolor supplement contains various phytochemicals, including phenolic acids and polyphenols such as proanthocyanidins. Sorghum bicolor supplement is particularly rich in 3-deoxyanthocyanins, such as luteolinidin and apigeninidin, and appears to induce apoptosis and inhibit cell proliferation in cancer cells through the stimulation of various apoptosis promoter genes and the downregulation of certain apoptosis inhibitor genes. In addition, due to the strong antioxidant nature of the phytochemicals, these compounds are able to scavenge free radicals and prevent tissue damage. Also, intake of this supplement modulates the immune system by both increasing the activity of natural killer (NK) cells and initiating the activation of macrophages.<\/div>\n<figure class=\"table\">\n<table class=\"synonym\" border=\"0\" width=\"100%\" cellspacing=\"0\" cellpadding=\"0\">\n<tbody>\n<tr>\n<th scope=\"row\" valign=\"top\" width=\"28%\"><b>Synonym:<\/b><\/th>\n<td valign=\"top\" width=\"68%\">sorghum bicolor extract<\/td>\n<\/tr>\n<tr>\n<th scope=\"row\" valign=\"top\" width=\"28%\"><b>Foreign brand name:<\/b><\/th>\n<td valign=\"top\" width=\"68%\">Jobelyn<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/figure>\n<\/div>\n<p>&nbsp;<\/p>\n<div class=\"ead-preview\"><div class=\"ead-document\" style=\"position: relative;\"><div class=\"ead-iframe-wrapper\"><iframe src=\"\/\/docs.google.com\/viewer?url=https%3A%2F%2Fjobelyn.com.ng%2Fng%2Fwp-content%2Fuploads%2F2021%2F10%2FJobelyn%C2%AE-show-potential-in-cancer-immunosurveillance-1.pdf&amp;embedded=true&amp;hl=en\" title=\"Embedded Document\" class=\"ead-iframe\" style=\"width: 50%;height: 50%;border: none;min-height: 500px;visibility: hidden;\"><\/iframe><\/div>\t\t\t<div class=\"ead-document-loading\" style=\"width:100%;height:100%;position:absolute;left:0;top:0;z-index:10;\">\n\t\t\t\t<div class=\"ead-loading-wrap\">\n\t\t\t\t\t<div class=\"ead-loading-main\">\n\t\t\t\t\t\t<div class=\"ead-loading\">\n\t\t\t\t\t\t\t<img decoding=\"async\" src=\"https:\/\/jobelyn.com.ng\/ng\/wp-content\/plugins\/embed-any-document\/images\/loading.svg\" width=\"55\" height=\"55\" alt=\"Loader\">\n\t\t\t\t\t\t\t<span>Loading...<\/span>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t\t<div class=\"ead-loading-foot\">\n\t\t\t\t\t\t<div class=\"ead-loading-foot-title\">\n\t\t\t\t\t\t\t<img decoding=\"async\" src=\"https:\/\/jobelyn.com.ng\/ng\/wp-content\/plugins\/embed-any-document\/images\/EAD-logo.svg\" alt=\"EAD Logo\" width=\"36\" height=\"23\"\/>\n\t\t\t\t\t\t\t<span>Taking too 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class=\"ead-iframe-wrapper\"><iframe src=\"\/\/docs.google.com\/viewer?url=https%3A%2F%2Fjobelyn.com.ng%2Fng%2Fwp-content%2Fuploads%2F2021%2F10%2FInternational-journal-of-rheumatoid-disease-Samira-Makanjuola.pdf&amp;embedded=true&amp;hl=en\" title=\"Embedded Document\" class=\"ead-iframe\" style=\"width: 100%;height: 100%;border: none;position: absolute;left: 0;top: 0;visibility: hidden;\"><\/iframe><\/div>\t\t\t<div class=\"ead-document-loading\" style=\"width:100%;height:100%;position:absolute;left:0;top:0;z-index:10;\">\n\t\t\t\t<div class=\"ead-loading-wrap\">\n\t\t\t\t\t<div class=\"ead-loading-main\">\n\t\t\t\t\t\t<div class=\"ead-loading\">\n\t\t\t\t\t\t\t<img decoding=\"async\" src=\"https:\/\/jobelyn.com.ng\/ng\/wp-content\/plugins\/embed-any-document\/images\/loading.svg\" width=\"55\" height=\"55\" alt=\"Loader\">\n\t\t\t\t\t\t\t<span>Loading...<\/span>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t\t<div class=\"ead-loading-foot\">\n\t\t\t\t\t\t<div class=\"ead-loading-foot-title\">\n\t\t\t\t\t\t\t<img decoding=\"async\" src=\"https:\/\/jobelyn.com.ng\/ng\/wp-content\/plugins\/embed-any-document\/images\/EAD-logo.svg\" alt=\"EAD Logo\" width=\"36\" height=\"23\"\/>\n\t\t\t\t\t\t\t<span>Taking too long?<\/span>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<div class=\"ead-document-btn ead-reload-btn\" role=\"button\">\n\t\t\t\t\t\t\t\t<img decoding=\"async\" src=\"https:\/\/jobelyn.com.ng\/ng\/wp-content\/plugins\/embed-any-document\/images\/reload.svg\" alt=\"Reload\" width=\"12\" height=\"12\"\/> Reload document\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<span>|<\/span>\n\t\t\t\t\t\t\t<a href=\"https:\/\/jobelyn.com.ng\/ng\/wp-content\/uploads\/2021\/10\/International-journal-of-rheumatoid-disease-Samira-Makanjuola.pdf\" class=\"ead-document-btn\" target=\"_blank\">\n\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/jobelyn.com.ng\/ng\/wp-content\/plugins\/embed-any-document\/images\/open.svg\" alt=\"Open\" width=\"12\" height=\"12\"\/> Open in new tab\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t<\/div><\/div>\n<p style=\"text-align: left;\"><div class=\"ead-preview\"><div class=\"ead-document\" style=\"position: relative;\"><div class=\"ead-iframe-wrapper\"><iframe src=\"\/\/docs.google.com\/viewer?url=https%3A%2F%2Fjobelyn.com.ng%2Fng%2Fwp-content%2Fuploads%2F2021%2F10%2FMD-3-3-096-1083_FinalReport.pdf&amp;embedded=true&amp;hl=en\" title=\"Embedded Document\" class=\"ead-iframe\" style=\"width: 50%;height: 50%;border: none;min-height: 500px;visibility: hidden;\"><\/iframe><\/div>\t\t\t<div class=\"ead-document-loading\" style=\"width:100%;height:100%;position:absolute;left:0;top:0;z-index:10;\">\n\t\t\t\t<div class=\"ead-loading-wrap\">\n\t\t\t\t\t<div class=\"ead-loading-main\">\n\t\t\t\t\t\t<div class=\"ead-loading\">\n\t\t\t\t\t\t\t<img decoding=\"async\" src=\"https:\/\/jobelyn.com.ng\/ng\/wp-content\/plugins\/embed-any-document\/images\/loading.svg\" width=\"55\" height=\"55\" alt=\"Loader\">\n\t\t\t\t\t\t\t<span>Loading...<\/span>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t\t<div class=\"ead-loading-foot\">\n\t\t\t\t\t\t<div class=\"ead-loading-foot-title\">\n\t\t\t\t\t\t\t<img decoding=\"async\" src=\"https:\/\/jobelyn.com.ng\/ng\/wp-content\/plugins\/embed-any-document\/images\/EAD-logo.svg\" alt=\"EAD Logo\" width=\"36\" height=\"23\"\/>\n\t\t\t\t\t\t\t<span>Taking too long?<\/span>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<div class=\"ead-document-btn ead-reload-btn\" role=\"button\">\n\t\t\t\t\t\t\t\t<img decoding=\"async\" src=\"https:\/\/jobelyn.com.ng\/ng\/wp-content\/plugins\/embed-any-document\/images\/reload.svg\" alt=\"Reload\" width=\"12\" height=\"12\"\/> Reload document\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<span>|<\/span>\n\t\t\t\t\t\t\t<a href=\"https:\/\/jobelyn.com.ng\/ng\/wp-content\/uploads\/2021\/10\/MD-3-3-096-1083_FinalReport.pdf\" class=\"ead-document-btn\" target=\"_blank\">\n\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/jobelyn.com.ng\/ng\/wp-content\/plugins\/embed-any-document\/images\/open.svg\" alt=\"Open\" width=\"12\" height=\"12\"\/> Open in new tab\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t<\/div><\/div>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p><a href=\"http:\/\/Sorghum [Sorghum bicolor (L.) Moench] Genotypes withContrasting Polyphenol Compositions Differentially Modulate Inflammatory Cytokines in Mouse Macrophages Davina H. Rhodes1 and Stephen Kresovich2\">Sorghum [Sorghum bicolor (L.) Moench] Genotypes withContrasting Polyphenol Compositions Differentially Modulate Inflammatory Cytokines in Mouse Macrophages<\/a><\/p>\n<p>Davina H. Rhodes1 and Stephen Kresovich2<br \/>\n1 Department of Human Nutrition, Kansas State University, Manhattan, KS 66503, USA<br \/>\n2 Department of Genetics and Biochemistry, Clemson University, Clemson, SC 29634, USA<\/p>\n<p>Correspondence should be addressed to Davina H. Rhodes; davinarhodes@gmail.com<\/p>\n<p>Received 4 March 2016; Revised 7 June 2016; Accepted 21 June 2016<br \/>\nAcademic Editor: Thaila C. Putarov<br \/>\nCopyright \u00a9 2016 D. H. Rhodes and S. Kresovich. This is an open access article distributed under the Creative Commons<br \/>\nAttribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is<br \/>\nproperly cited.<\/p>\n<p>This study sought to characterize and compare anti-inflammatory effects of twenty sorghum accessions with contrasting grain polyphenol concentrations but similar genetic backgrounds (based on a genomewide estimate of relatedness). Cell viability, tumor necrosis factor- (TNF-) \ud835\udefc, and interleukin- (IL-) 6 were measured in RAW 264.7 macrophages treated with increasing doses (0,15, 30, and 60 \ud835\udf07g\/mL) of sorghum ethanol extracts and stimulated with lipopolysaccharide (LPS). Extract dose had a significan effect on TNF-\ud835\udefc and IL-6, with a trend of cytokines decreasing between 0 \ud835\udf07g\/mL and 15 \ud835\udf07g\/mL of sorghum extract. Genotypealso had a significant effect on the cytokines, with extracts from four accessions significantly decreasing TNF-\ud835\udefc and\/or IL-6.<br \/>\nCells treated with 3-deoxyanthocyanidin-containing accessions had less cytokine production than non-3-deoxyanthocyanidin accessions, whereas cells treated with proanthocyanidin-containing accessions had more cytokine production than cells treated with nonproanthocyanidin accessions. Additionally, there was a significant effect of the Tannin1 allele on TNF-\ud835\udefc and IL-6. Our results demonstrate that sorghum genotypes differentially modulate induction of inflammatory cytokine production in RAW 264.7 macrophages and that specialty grain has the potential to be tailored by controlling traits at the nucleotide level. This study adds to our knowledge of sorghum health effects and contributes to efforts aimed at developing health-promoting sorghum grain.<\/p>\n<p><a href=\"https:\/\/jobelyn.com.ng\/ng\/wp-content\/uploads\/2021\/10\/Sorghum_Sorghum_bicolor_L_Moench_Genotypes_with_Co.pdf\">Sorghum_Sorghum_bicolor_L_Moench_Genotypes_with_Co<\/a><\/p>\n<div class=\"ead-preview\"><div class=\"ead-document\" style=\"position: relative;\"><div class=\"ead-iframe-wrapper\"><iframe src=\"\/\/docs.google.com\/viewer?url=https%3A%2F%2Fjobelyn.com.ng%2Fng%2Fwp-content%2Fuploads%2F2021%2F10%2FSorghum_Sorghum_bicolor_L_Moench_Genotypes_with_Co.pdf&amp;embedded=true&amp;hl=en\" title=\"Embedded Document\" class=\"ead-iframe\" style=\"width: 50%;height: 50%;border: none;min-height: 500px;visibility: hidden;\"><\/iframe><\/div>\t\t\t<div class=\"ead-document-loading\" style=\"width:100%;height:100%;position:absolute;left:0;top:0;z-index:10;\">\n\t\t\t\t<div class=\"ead-loading-wrap\">\n\t\t\t\t\t<div class=\"ead-loading-main\">\n\t\t\t\t\t\t<div class=\"ead-loading\">\n\t\t\t\t\t\t\t<img decoding=\"async\" src=\"https:\/\/jobelyn.com.ng\/ng\/wp-content\/plugins\/embed-any-document\/images\/loading.svg\" width=\"55\" height=\"55\" alt=\"Loader\">\n\t\t\t\t\t\t\t<span>Loading...<\/span>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t\t<div class=\"ead-loading-foot\">\n\t\t\t\t\t\t<div class=\"ead-loading-foot-title\">\n\t\t\t\t\t\t\t<img decoding=\"async\" src=\"https:\/\/jobelyn.com.ng\/ng\/wp-content\/plugins\/embed-any-document\/images\/EAD-logo.svg\" alt=\"EAD Logo\" width=\"36\" height=\"23\"\/>\n\t\t\t\t\t\t\t<span>Taking too long?<\/span>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<div class=\"ead-document-btn ead-reload-btn\" role=\"button\">\n\t\t\t\t\t\t\t\t<img decoding=\"async\" src=\"https:\/\/jobelyn.com.ng\/ng\/wp-content\/plugins\/embed-any-document\/images\/reload.svg\" alt=\"Reload\" width=\"12\" height=\"12\"\/> Reload document\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<span>|<\/span>\n\t\t\t\t\t\t\t<a href=\"https:\/\/jobelyn.com.ng\/ng\/wp-content\/uploads\/2021\/10\/Sorghum_Sorghum_bicolor_L_Moench_Genotypes_with_Co.pdf\" class=\"ead-document-btn\" target=\"_blank\">\n\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/jobelyn.com.ng\/ng\/wp-content\/plugins\/embed-any-document\/images\/open.svg\" alt=\"Open\" width=\"12\" height=\"12\"\/> Open in new tab\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t<\/div><\/div>\n<ol>\n<li style=\"text-align: center;\"><div class=\"ead-preview\"><div class=\"ead-document\" style=\"position: relative;\"><iframe src=\"\/\/view.officeapps.live.com\/op\/embed.aspx?src=https%3A%2F%2Fjobelyn.com.ng%2Fng%2Fwp-content%2Fuploads%2F2021%2F10%2FJ-JA-JE-JE5-P8-P9-CHARTS-JUNE-12-2020.pptx\" title=\"Embedded Document\" class=\"ead-iframe\" style=\"width: 50%;height: 50%;border: none;min-height: 500px;\"><\/iframe><\/div><\/div><\/li>\n<\/ol>\n","protected":false},"excerpt":{"rendered":"<p>&nbsp; FROM NATIONAL CANCER INSTITUTE WEBSITE8 Sorghum bicolor supplement An herbal-based nutritional supplement containing the leaf sheaths of the plant Sorghum bicolor, with potential antioxidant, anti-inflammatory, chemopreventive and immunomodulating activities. Sorghum bicolor supplement contains various phytochemicals, including phenolic acids and polyphenols such as proanthocyanidins. Sorghum bicolor supplement is particularly rich in 3-deoxyanthocyanins, such as luteolinidin&hellip;<\/p>\n","protected":false},"author":93,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-6382","post","type-post","status-publish","format-standard","hentry","category-uncategorized"],"_links":{"self":[{"href":"https:\/\/jobelyn.com.ng\/ng\/wp-json\/wp\/v2\/posts\/6382","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/jobelyn.com.ng\/ng\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/jobelyn.com.ng\/ng\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/jobelyn.com.ng\/ng\/wp-json\/wp\/v2\/users\/93"}],"replies":[{"embeddable":true,"href":"https:\/\/jobelyn.com.ng\/ng\/wp-json\/wp\/v2\/comments?post=6382"}],"version-history":[{"count":5,"href":"https:\/\/jobelyn.com.ng\/ng\/wp-json\/wp\/v2\/posts\/6382\/revisions"}],"predecessor-version":[{"id":6398,"href":"https:\/\/jobelyn.com.ng\/ng\/wp-json\/wp\/v2\/posts\/6382\/revisions\/6398"}],"wp:attachment":[{"href":"https:\/\/jobelyn.com.ng\/ng\/wp-json\/wp\/v2\/media?parent=6382"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/jobelyn.com.ng\/ng\/wp-json\/wp\/v2\/categories?post=6382"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/jobelyn.com.ng\/ng\/wp-json\/wp\/v2\/tags?post=6382"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}