{"id":7600,"date":"2024-04-18T03:18:58","date_gmt":"2024-04-18T03:18:58","guid":{"rendered":"https:\/\/jobelyn.com.ng\/ng\/?p=7600"},"modified":"2024-04-18T03:18:58","modified_gmt":"2024-04-18T03:18:58","slug":"apigeninidin-rich-sorghum-bicolor-l-moench-extracts-suppress-a549-cells-proliferation-and-ameliorate-toxicity-of-aflatoxin-b1-mediated-liver-and-kidney-derangement-in-rats","status":"publish","type":"post","link":"https:\/\/jobelyn.com.ng\/ng\/2024\/04\/18\/apigeninidin-rich-sorghum-bicolor-l-moench-extracts-suppress-a549-cells-proliferation-and-ameliorate-toxicity-of-aflatoxin-b1-mediated-liver-and-kidney-derangement-in-rats\/","title":{"rendered":"Apigeninidin-rich Sorghum bicolor (L. Moench) extracts suppress A549 cells proliferation and ameliorate toxicity of aflatoxin B1-mediated liver and kidney derangement in rats"},"content":{"rendered":"<p>&nbsp;<\/p>\n<p><a href=\"https:\/\/jobelyn.com.ng\/ng\/wp-content\/uploads\/2022\/09\/Apigeninidin-rich-Sorghum-bicolor-L.-Moench-extracts-suppress-A549-cells-proliferation-and-ameliorate-toxicity-of-aflatoxin-B1-mediated-liver-and-kidney-derangement-in-rats_.pdf\">Apigeninidin-rich\u00a0Sorghum bicolor\u00a0(L. Moench) extracts suppress A549 cells proliferation and ameliorate toxicity of aflatoxin B1-mediated liver and kidney derangement in rats_<\/a><\/p>\n<div class=\"ead-preview\"><div class=\"ead-document\" style=\"position: relative;padding-top: 90%;\"><div class=\"ead-iframe-wrapper\"><iframe src=\"\/\/docs.google.com\/viewer?url=https%3A%2F%2Fjobelyn.com.ng%2Fng%2Fwp-content%2Fuploads%2F2022%2F09%2FApigeninidin-rich-Sorghum-bicolor-L.-Moench-extracts-suppress-A549-cells-proliferation-and-ameliorate-toxicity-of-aflatoxin-B1-mediated-liver-and-kidney-derangement-in-rats_.pdf&amp;embedded=true&amp;hl=en\" title=\"Embedded Document\" class=\"ead-iframe\" style=\"width: 100%;height: 100%;border: none;position: absolute;left: 0;top: 0;visibility: hidden;\"><\/iframe><\/div>\t\t\t<div class=\"ead-document-loading\" style=\"width:100%;height:100%;position:absolute;left:0;top:0;z-index:10;\">\n\t\t\t\t<div class=\"ead-loading-wrap\">\n\t\t\t\t\t<div class=\"ead-loading-main\">\n\t\t\t\t\t\t<div class=\"ead-loading\">\n\t\t\t\t\t\t\t<img decoding=\"async\" src=\"https:\/\/jobelyn.com.ng\/ng\/wp-content\/plugins\/embed-any-document\/images\/loading.svg\" width=\"55\" height=\"55\" alt=\"Loader\">\n\t\t\t\t\t\t\t<span>Loading...<\/span>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t\t<div class=\"ead-loading-foot\">\n\t\t\t\t\t\t<div class=\"ead-loading-foot-title\">\n\t\t\t\t\t\t\t<img decoding=\"async\" src=\"https:\/\/jobelyn.com.ng\/ng\/wp-content\/plugins\/embed-any-document\/images\/EAD-logo.svg\" alt=\"EAD Logo\" width=\"36\" height=\"23\"\/>\n\t\t\t\t\t\t\t<span>Taking too long?<\/span>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<div class=\"ead-document-btn ead-reload-btn\" role=\"button\">\n\t\t\t\t\t\t\t\t<img decoding=\"async\" src=\"https:\/\/jobelyn.com.ng\/ng\/wp-content\/plugins\/embed-any-document\/images\/reload.svg\" alt=\"Reload\" width=\"12\" height=\"12\"\/> Reload document\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<span>|<\/span>\n\t\t\t\t\t\t\t<a href=\"https:\/\/jobelyn.com.ng\/ng\/wp-content\/uploads\/2022\/09\/Apigeninidin-rich-Sorghum-bicolor-L.-Moench-extracts-suppress-A549-cells-proliferation-and-ameliorate-toxicity-of-aflatoxin-B1-mediated-liver-and-kidney-derangement-in-rats_.pdf\" class=\"ead-document-btn\" target=\"_blank\">\n\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/jobelyn.com.ng\/ng\/wp-content\/plugins\/embed-any-document\/images\/open.svg\" alt=\"Open\" width=\"12\" height=\"12\"\/> Open in new tab\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t<\/div><\/div>\n<p>Since\u00a0<i>S. bicolor<\/i>\u00a0sheaths contain active principles with antioxidant, anti-inflammatory and chemo-preventive activities, we hypothesise that our extracts are more likely to alleviate the toxic effects of AFB<sub>1<\/sub>\u00a0in the rat model. We considered the AFB<sub>1<\/sub>\u00a0model of toxicity because it has been reported that AFB<sub>1<\/sub>\u00a0exposure orchestrates hepatocellular carcinoma<sup><a id=\"ref-link-section-d209807190e3420\" title=\"Hamid, A. S., Tesfamariam, I. G., Zhang, Y. &amp; Zhang, Z. G. Aflatoxin B1-induced hepatocellular carcinoma in developing countries: Geographical distribution, mechanism of action and prevention. Oncol. Lett. 5, 1087\u20131092. https:\/\/doi.org\/10.3892\/ol.2013.1169 (2013).\" href=\"https:\/\/www.nature.com\/articles\/s41598-022-10926-1#ref-CR95\" data-track=\"click\" data-track-action=\"reference anchor\" data-track-label=\"link\" data-test=\"citation-ref\" aria-label=\"Reference 95\">95<\/a><\/sup>\u00a0and lung adenocarcinoma in humans<sup><a id=\"ref-link-section-d209807190e3425\" title=\"Donnelly, P. J. et al. Biotransformation of aflatoxin B1 in human lung. Carcinogenesis 17, 2487\u20132494. https:\/\/doi.org\/10.1093\/carcin\/17.11.2487 (1996).\" href=\"https:\/\/www.nature.com\/articles\/s41598-022-10926-1#ref-CR96\" data-track=\"click\" data-track-action=\"reference anchor\" data-track-label=\"link\" data-test=\"citation-ref\" aria-label=\"Reference 96\">96<\/a><\/sup>, thus making it a public health issue globally<sup><a id=\"ref-link-section-d209807190e3429\" title=\"Kucukcakan, B. &amp; Hayrulai-Musliu, Z. Challenging role of dietary aflatoxin B1 exposure and hepatitis b infection on risk of hepatocellular carcinoma. Open Access Maced. J. Med. Sci. 3, 363\u2013369. https:\/\/doi.org\/10.3889\/oamjms.2015.032 (2015).\" href=\"https:\/\/www.nature.com\/articles\/s41598-022-10926-1#ref-CR97\" data-track=\"click\" data-track-action=\"reference anchor\" data-track-label=\"link\" data-test=\"citation-ref\" aria-label=\"Reference 97\">97<\/a>,<a id=\"ref-link-section-d209807190e3432\" title=\"Nugraha, A. 0, Khotimah, K. &amp; Rietjens, I. M. C. M. Risk assessment of aflatoxin B1 exposure from maize and peanut consumption in Indonesia using the margin of exposure and liver cancer risk estimation approaches. Food Chem. Toxicolx 113, 134\u2013144 (2018).\" href=\"https:\/\/www.nature.com\/articles\/s41598-022-10926-1#ref-CR98\" data-track=\"click\" data-track-action=\"reference anchor\" data-track-label=\"link\" data-test=\"citation-ref\" aria-label=\"Reference 98\">98<\/a><\/sup>.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>&nbsp; Apigeninidin-rich\u00a0Sorghum bicolor\u00a0(L. Moench) extracts suppress A549 cells proliferation and ameliorate toxicity of aflatoxin B1-mediated liver and kidney derangement in rats_ Since\u00a0S. bicolor\u00a0sheaths contain active principles with antioxidant, anti-inflammatory and chemo-preventive activities, we hypothesise that our extracts are more likely to alleviate the toxic effects of AFB1\u00a0in the rat model. We considered the AFB1\u00a0model of&hellip;<\/p>\n","protected":false},"author":93,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-7600","post","type-post","status-publish","format-standard","hentry","category-uncategorized"],"_links":{"self":[{"href":"https:\/\/jobelyn.com.ng\/ng\/wp-json\/wp\/v2\/posts\/7600","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/jobelyn.com.ng\/ng\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/jobelyn.com.ng\/ng\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/jobelyn.com.ng\/ng\/wp-json\/wp\/v2\/users\/93"}],"replies":[{"embeddable":true,"href":"https:\/\/jobelyn.com.ng\/ng\/wp-json\/wp\/v2\/comments?post=7600"}],"version-history":[{"count":2,"href":"https:\/\/jobelyn.com.ng\/ng\/wp-json\/wp\/v2\/posts\/7600\/revisions"}],"predecessor-version":[{"id":7603,"href":"https:\/\/jobelyn.com.ng\/ng\/wp-json\/wp\/v2\/posts\/7600\/revisions\/7603"}],"wp:attachment":[{"href":"https:\/\/jobelyn.com.ng\/ng\/wp-json\/wp\/v2\/media?parent=7600"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/jobelyn.com.ng\/ng\/wp-json\/wp\/v2\/categories?post=7600"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/jobelyn.com.ng\/ng\/wp-json\/wp\/v2\/tags?post=7600"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}