{"id":7795,"date":"2024-04-18T03:18:03","date_gmt":"2024-04-18T03:18:03","guid":{"rendered":"https:\/\/jobelyn.com.ng\/ng\/?p=7795"},"modified":"2024-04-18T03:18:57","modified_gmt":"2024-04-18T03:18:57","slug":"antioxidant-and-antiproliferating-effects-of-setaria-italica-panicum-miliaceum-and-sorghum-bicolor-extracts-on-prostate-cancer-cell-lines","status":"publish","type":"post","link":"https:\/\/jobelyn.com.ng\/ng\/2024\/04\/18\/antioxidant-and-antiproliferating-effects-of-setaria-italica-panicum-miliaceum-and-sorghum-bicolor-extracts-on-prostate-cancer-cell-lines\/","title":{"rendered":"Antioxidant and antiproliferating effects of Setaria italica, Panicum  miliaceum and Sorghum bicolor extracts on prostate cancer cell lines"},"content":{"rendered":"<p>&nbsp;<\/p>\n<p><iframe id=\"gt-nvframe\" title=\"Google Translate navigation\" role=\"navigation\" 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href=\"https:\/\/koreascience-kr.translate.goog\/journal\/SPOSBX\/v23n7.page?_x_tr_sl=auto&amp;_x_tr_tl=en&amp;_x_tr_hl=en&amp;_x_tr_pto=wapp\">Volume 23 Issue 7<\/a><\/li>\n<li class=\"list-inline-item\">\/<\/li>\n<li class=\"list-inline-item\">Pages.1033-1041<\/li>\n<li class=\"list-inline-item\">\/<\/li>\n<li class=\"list-inline-item\">2016<\/li>\n<li class=\"list-inline-item\">\/<\/li>\n<li class=\"list-inline-item\">1738-7248 (pISSN)<\/li>\n<li class=\"list-inline-item\">\/<\/li>\n<li class=\"list-inline-item\">2287-7428 (eISSN)<\/li>\n<\/ul>\n<p><a class=\"u-link-v5 g-color-secondary-dark-v1 g-color-primary--hover\" href=\"https:\/\/koreascience-kr.translate.goog\/publisher\/postap.page?_x_tr_sl=auto&amp;_x_tr_tl=en&amp;_x_tr_hl=en&amp;_x_tr_pto=wapp\">The Korean Society of Food Preservation<\/a><\/p>\n<\/div>\n<\/div>\n<div class=\"contenting\">\n<div class=\"row contents-table article-title-row border-bottom\">\n<div class=\"col-md-12\">\n<h1 id=\"h-1\" class=\"h2 article-title\" title=\"Antioxidant and antiproliferating effects of Setaria italica, Panicum miliaceum and Sorghum bicolor extracts on prostate cancer cell lines\">Antioxidant and antiproliferating effects of Setaria italica, Panicum miliaceum and Sorghum bicolor extracts on prostate cancer cell lines<\/h1>\n<h1 id=\"h-2\" class=\"h2 g-mb-15\" title=\"Antioxidant effect and inhibition of prostate cancer cell line proliferation of millet, millet, and sorghum extracts\">Antioxidant effect and inhibition of prostate cancer cell line proliferation of millet, millet, and sorghum extracts<\/h1>\n<\/div>\n<\/div>\n<div class=\"row\">\n<div class=\"col-md-12\">\n<ul class=\"list-inline g-color-gray-dark-v2 m0\">\n<li class=\"list-inline-item\"><a href=\"https:\/\/translate.google.com\/website?sl=auto&amp;tl=en&amp;hl=en&amp;client=webapp&amp;u=http:\/\/doi.or.kr\/10.PSN\/ADPER8201214669\" target=\"_blank\" rel=\"noopener\">Kim, Jeong-Ho<\/a>\u00a0(Department of Food and Nutrition, Sunchon National University) ;<\/li>\n<li class=\"list-inline-item\"><a href=\"https:\/\/translate.google.com\/website?sl=auto&amp;tl=en&amp;hl=en&amp;client=webapp&amp;u=http:\/\/doi.or.kr\/10.PSN\/ADPER6801461013\" target=\"_blank\" rel=\"noopener\">Cho, Hyun-Dong<\/a>\u00a0(Department of Food Science and Biotechnology, Kyungpook National University) ;<a title=\"ISNI:000000046807724X\" href=\"https:\/\/translate.google.com\/website?sl=auto&amp;tl=en&amp;hl=en&amp;client=webapp&amp;u=http:\/\/nl.go.kr\/isni\/000000046807724X\" target=\"_blank\" rel=\"noopener\">\u00a0<img decoding=\"async\" src=\"https:\/\/koreascience.kr\/image\/isni-logo2-xs.png\" \/><\/a><\/li>\n<li class=\"list-inline-item\"><a href=\"https:\/\/translate.google.com\/website?sl=auto&amp;tl=en&amp;hl=en&amp;client=webapp&amp;u=http:\/\/doi.or.kr\/10.PSN\/ADPER6802879112\" target=\"_blank\" rel=\"noopener\">Hong, Seong-Min<\/a>\u00a0(Department of Biotechnology, Dong-A University) ;<a title=\"ISNI:0000000468109272\" href=\"https:\/\/translate.google.com\/website?sl=auto&amp;tl=en&amp;hl=en&amp;client=webapp&amp;u=http:\/\/nl.go.kr\/isni\/0000000468109272\" target=\"_blank\" rel=\"noopener\">\u00a0<img decoding=\"async\" src=\"https:\/\/koreascience.kr\/image\/isni-logo2-xs.png\" \/><\/a><\/li>\n<li class=\"list-inline-item\"><a href=\"https:\/\/translate.google.com\/website?sl=auto&amp;tl=en&amp;hl=en&amp;client=webapp&amp;u=http:\/\/doi.or.kr\/10.PSN\/ADPER0000273704\" target=\"_blank\" rel=\"noopener\">Lee, Ju-Hye<\/a>\u00a0(Functional Food and Nutrition Division, Department of Agro-Food Resource, National Academy of Agricultural Science, Rural Development Administration) ;<\/li>\n<li class=\"list-inline-item\"><a href=\"https:\/\/translate.google.com\/website?sl=auto&amp;tl=en&amp;hl=en&amp;client=webapp&amp;u=http:\/\/doi.or.kr\/10.PSN\/ADPER0000071761\" target=\"_blank\" rel=\"noopener\">Lee, Yong-Seok<\/a>\u00a0(Department of Biotechnology, Dong-A University) ;<a title=\"ISNI:0000000464624111\" href=\"https:\/\/translate.google.com\/website?sl=auto&amp;tl=en&amp;hl=en&amp;client=webapp&amp;u=http:\/\/nl.go.kr\/isni\/0000000464624111\" target=\"_blank\" rel=\"noopener\">\u00a0<img decoding=\"async\" src=\"https:\/\/koreascience.kr\/image\/isni-logo2-xs.png\" \/><\/a><\/li>\n<li class=\"list-inline-item\"><a href=\"https:\/\/translate.google.com\/website?sl=auto&amp;tl=en&amp;hl=en&amp;client=webapp&amp;u=http:\/\/doi.or.kr\/10.PSN\/ADPER0000036810\" target=\"_blank\" rel=\"noopener\">Kim, Du-Hyun<\/a>\u00a0(Department of Life Resources Industry, Dong-A University) ;<\/li>\n<li class=\"list-inline-item\"><a href=\"https:\/\/translate.google.com\/website?sl=auto&amp;tl=en&amp;hl=en&amp;client=webapp&amp;u=http:\/\/doi.or.kr\/10.PSN\/ADPER0000053713\" target=\"_blank\" rel=\"noopener\">Seo, Kwon-Il<\/a>\u00a0(Department of Biotechnology, Dong-A University)<a title=\"ISNI:0000000459883143\" href=\"https:\/\/translate.google.com\/website?sl=auto&amp;tl=en&amp;hl=en&amp;client=webapp&amp;u=http:\/\/nl.go.kr\/isni\/0000000459883143\" target=\"_blank\" rel=\"noopener\">\u00a0<img decoding=\"async\" src=\"https:\/\/koreascience.kr\/image\/isni-logo2-xs.png\" \/><\/a><\/li>\n<\/ul>\n<ul class=\"list-inline g-color-gray-dark-v2\">\n<li class=\"list-inline-item\"><a href=\"https:\/\/translate.google.com\/website?sl=auto&amp;tl=en&amp;hl=en&amp;client=webapp&amp;u=http:\/\/doi.or.kr\/10.PSN\/ADPER8201214669\" target=\"_blank\" rel=\"noopener\">Kim, Jeong- Ho<\/a>\u00a0(Dept. of Food and Nutrition, Sunchon National University) ;<\/li>\n<li class=\"list-inline-item\"><a href=\"https:\/\/translate.google.com\/website?sl=auto&amp;tl=en&amp;hl=en&amp;client=webapp&amp;u=http:\/\/doi.or.kr\/10.PSN\/ADPER6801461013\" target=\"_blank\" rel=\"noopener\">Cho<\/a>\u00a0, Hyun-Dong (Department of Food Science and Technology, Kyungpook National University) ;<a title=\"ISNI:000000046807724X\" href=\"https:\/\/translate.google.com\/website?sl=auto&amp;tl=en&amp;hl=en&amp;client=webapp&amp;u=http:\/\/nl.go.kr\/isni\/000000046807724X\" target=\"_blank\" rel=\"noopener\">\u00a0<img decoding=\"async\" src=\"https:\/\/koreascience.kr\/image\/isni-logo2-xs.png\" \/><\/a><\/li>\n<li class=\"list-inline-item\"><a href=\"https:\/\/translate.google.com\/website?sl=auto&amp;tl=en&amp;hl=en&amp;client=webapp&amp;u=http:\/\/doi.or.kr\/10.PSN\/ADPER6802879112\" target=\"_blank\" rel=\"noopener\">Hong<\/a>\u00a0, Seong-Min (Department of Biotechnology, Dong-A University) ;<a title=\"ISNI:0000000468109272\" href=\"https:\/\/translate.google.com\/website?sl=auto&amp;tl=en&amp;hl=en&amp;client=webapp&amp;u=http:\/\/nl.go.kr\/isni\/0000000468109272\" target=\"_blank\" rel=\"noopener\">\u00a0<img decoding=\"async\" src=\"https:\/\/koreascience.kr\/image\/isni-logo2-xs.png\" \/><\/a><\/li>\n<li class=\"list-inline-item\"><a href=\"https:\/\/translate.google.com\/website?sl=auto&amp;tl=en&amp;hl=en&amp;client=webapp&amp;u=http:\/\/doi.or.kr\/10.PSN\/ADPER0000273704\" target=\"_blank\" rel=\"noopener\">Joo<\/a>\u00a0-Hye Lee (Functional Food Division, Ministry of Agriculture and Food Resources, National Academy of Agricultural Science, Rural Development Administration) ;<\/li>\n<li class=\"list-inline-item\"><a href=\"https:\/\/translate.google.com\/website?sl=auto&amp;tl=en&amp;hl=en&amp;client=webapp&amp;u=http:\/\/doi.or.kr\/10.PSN\/ADPER0000071761\" target=\"_blank\" rel=\"noopener\">Lee Yong- Seok<\/a>\u00a0(Department of Biotechnology, Dong-A University) ;<a title=\"ISNI:0000000464624111\" href=\"https:\/\/translate.google.com\/website?sl=auto&amp;tl=en&amp;hl=en&amp;client=webapp&amp;u=http:\/\/nl.go.kr\/isni\/0000000464624111\" target=\"_blank\" rel=\"noopener\">\u00a0<img decoding=\"async\" src=\"https:\/\/koreascience.kr\/image\/isni-logo2-xs.png\" \/><\/a><\/li>\n<li class=\"list-inline-item\"><a href=\"https:\/\/translate.google.com\/website?sl=auto&amp;tl=en&amp;hl=en&amp;client=webapp&amp;u=http:\/\/doi.or.kr\/10.PSN\/ADPER0000036810\" target=\"_blank\" rel=\"noopener\">Kim<\/a>\u00a0, Du-Hyun (Department of Life Resources Industry, Dong-A University) ;<\/li>\n<li class=\"list-inline-item\"><a href=\"https:\/\/translate.google.com\/website?sl=auto&amp;tl=en&amp;hl=en&amp;client=webapp&amp;u=http:\/\/doi.or.kr\/10.PSN\/ADPER0000053713\" target=\"_blank\" rel=\"noopener\">Kwon<\/a>\u00a0-Il Seo (Department of Biotechnology, Dong-A University)<a title=\"ISNI:0000000459883143\" href=\"https:\/\/translate.google.com\/website?sl=auto&amp;tl=en&amp;hl=en&amp;client=webapp&amp;u=http:\/\/nl.go.kr\/isni\/0000000459883143\" target=\"_blank\" rel=\"noopener\">\u00a0<img decoding=\"async\" src=\"https:\/\/koreascience.kr\/image\/isni-logo2-xs.png\" \/><\/a><\/li>\n<\/ul>\n<ul class=\"list-inline\">\n<li class=\"list-inline-item\">Received : 2016.11.03<\/li>\n<li class=\"list-inline-item\">Accepted : 2016.12.06<\/li>\n<li class=\"list-inline-item\">Published : 2016.12.30<\/li>\n<\/ul>\n<ul class=\"list-inline\">\n<li class=\"list-inline-item\">\n<p class=\"g-color-gray-dark-v2\"><a class=\"btn btn-link pl0\" href=\"https:\/\/translate.google.com\/website?sl=auto&amp;tl=en&amp;hl=en&amp;client=webapp&amp;u=https:\/\/doi.org\/10.11002\/kjfp.2016.23.7.1033\" target=\"_blank\" rel=\"noopener\">https:\/\/doi.org\/10.11002\/kjfp.2016.23.7.1033<\/a>\u00a0<button class=\"btn btn-sm btn-outline-secondary func-copy\" type=\"button\">Copy<\/button>\u00a0<a class=\"btn btn-sm btn-outline-success\" href=\"https:\/\/translate.google.com\/website?sl=auto&amp;tl=en&amp;hl=en&amp;client=webapp&amp;u=http:\/\/data.doi.or.kr\/cite\/10.11002\/kjfp.2016.23.7.1033\" target=\"_blank\" rel=\"noopener\">Citation<\/a>\u00a0<a class=\"d-lg-none btn btn-sm btn-outline-danger\" href=\"https:\/\/koreascience-kr.translate.goog\/article\/JAKO201609633504282.pdf?_x_tr_sl=auto&amp;_x_tr_tl=en&amp;_x_tr_hl=en&amp;_x_tr_pto=wapp\" target=\"_blank\" rel=\"noopener\">PDF<\/a>\u00a0<a class=\"btn btn-sm btn-outline-primary\" href=\"https:\/\/koreascience-kr.translate.goog\/ksci\/search\/article\/articleView.ksci?articleBean.atclMgntNo=SPOSBX_2016_v23n7_1033&amp;_x_tr_sl=auto&amp;_x_tr_tl=en&amp;_x_tr_hl=en&amp;_x_tr_pto=wapp\" target=\"_blank\" rel=\"noopener\">KSCI<\/a><\/p>\n<\/li>\n<\/ul>\n<\/div>\n<\/div>\n<hr \/>\n<div class=\"row\">\n<div class=\"col-12 col-lg-8\">\n<div class=\"article-box\">\n<h4 id=\"h-3\" class=\"h4 g-mb-15 article-con-title\">Abstract<\/h4>\n<p class=\"g-color-gray-dark-v2 text-justify\">In this study, we evaluated antioxidant and antiproliferating effects of Setaria italica extract (SIE), Panicum miliaceum extract (PME) and Sorghum bicolor extract (SBE).\u00a0Antioxidant effects of these extracts were determined by assessing DPPH radical scavenging activity,\u00a0<span id=\"MathJax-Element-1-Frame\" class=\"mjx-chtml MathJax_CHTML\" style=\"box-sizing: border-box; display: inline-block; line-height: 0; text-indent: 0px; text-align: left; text-transform: none; font-style: normal; font-weight: normal; font-size: 16.66px; letter-spacing: normal; overflow-wrap: normal; word-spacing: normal; white-space: nowrap; float: none; direction: ltr; max-width: none; max-height: none; min-width: 0px; min-height: 0px; border: 0px; margin: 0px; padding: 1px 0px; position: relative;\" tabindex=\"0\" role=\"presentation\" data-mathml=\"&lt;math xmlns=&quot;http:\/\/www.w3.org\/1998\/Math\/MathML&quot;&gt;&lt;mi&gt;A&lt;\/mi&gt;&lt;mi&gt;B&lt;\/mi&gt;&lt;mi&gt;T&lt;\/mi&gt;&lt;msup&gt;&lt;mi&gt;S&lt;\/mi&gt;&lt;mo&gt;+&lt;\/mo&gt;&lt;\/msup&gt;&lt;\/math&gt;\"><span id=\"MJXc-Node-1\" class=\"mjx-math\" aria-hidden=\"true\"><span id=\"MJXc-Node-2\" class=\"mjx-mrow\"><span id=\"MJXc-Node-3\" class=\"mjx-mi\"><span class=\"mjx-char MJXc-TeX-math-I\">A<\/span><\/span><span id=\"MJXc-Node-4\" class=\"mjx-mi\"><span class=\"mjx-char MJXc-TeX-math-I\">B<\/span><\/span><span id=\"MJXc-Node-5\" class=\"mjx-mi\"><span class=\"mjx-char MJXc-TeX-math-I\">T<\/span><\/span><span id=\"MJXc-Node-6\" class=\"mjx-msubsup\"><span class=\"mjx-base\"><span id=\"MJXc-Node-7\" class=\"mjx-mi\"><span class=\"mjx-char MJXc-TeX-math-I\">S<\/span><\/span><\/span><span class=\"mjx-sup\"><span id=\"MJXc-Node-8\" class=\"mjx-mo\"><span class=\"mjx-char MJXc-TeX-main-R\">+<\/span><\/span><\/span><\/span><\/span><\/span><span class=\"MJX_Assistive_MathML\" role=\"presentation\">ABTS+<\/span><\/span>\u00a0radical scavenging activity, reducing power and superoxide dismutase (SOD)-like activity.\u00a0From high concentrations (\u00a0<span id=\"MathJax-Element-2-Frame\" class=\"mjx-chtml MathJax_CHTML\" style=\"box-sizing: border-box; display: inline-block; line-height: 0; text-indent: 0px; text-align: left; text-transform: none; font-style: normal; font-weight: normal; font-size: 21.7px; letter-spacing: normal; overflow-wrap: normal; word-spacing: normal; white-space: nowrap; float: none; direction: ltr; max-width: none; max-height: none; min-width: 0px; min-height: 0px; border: 0px; margin: 0px; padding: 1px 0px; position: relative;\" tabindex=\"0\" role=\"presentation\" data-mathml=\"&lt;math xmlns=&quot;http:\/\/www.w3.org\/1998\/Math\/MathML&quot;&gt;&lt;mn&gt;1&lt;\/mn&gt;&lt;mo&gt;,&lt;\/mo&gt;&lt;mn&gt;000&lt;\/mn&gt;&lt;mrow class=&quot;MJX-TeXAtom-ORD&quot;&gt;&lt;mi&gt;&amp;#x03BC;&lt;\/mi&gt;&lt;\/mrow&gt;&lt;mi&gt;g&lt;\/mi&gt;&lt;mrow class=&quot;MJX-TeXAtom-ORD&quot;&gt;&lt;mo&gt;\/&lt;\/mo&gt;&lt;\/mrow&gt;&lt;mi&gt;m&lt;\/mi&gt;&lt;mi&gt;L&lt;\/mi&gt;&lt;\/math&gt;\"><span id=\"MJXc-Node-9\" class=\"mjx-math\" aria-hidden=\"true\"><span id=\"MJXc-Node-10\" class=\"mjx-mrow\"><span id=\"MJXc-Node-11\" class=\"mjx-mn\"><span class=\"mjx-char MJXc-TeX-main-R\">One<\/span><\/span><span id=\"MJXc-Node-12\" class=\"mjx-mo\"><span class=\"mjx-char MJXc-TeX-main-R\">,<\/span><\/span><span id=\"MJXc-Node-13\" class=\"mjx-mn MJXc-space1\"><span class=\"mjx-char MJXc-TeX-main-R\">000<\/span><\/span><span id=\"MJXc-Node-14\" class=\"mjx-texatom\"><span id=\"MJXc-Node-15\" class=\"mjx-mrow\"><span id=\"MJXc-Node-16\" class=\"mjx-mi\"><span class=\"mjx-char MJXc-TeX-math-I\">\u03bc<\/span><\/span><\/span><\/span><span id=\"MJXc-Node-17\" class=\"mjx-mi\"><span class=\"mjx-char MJXc-TeX-math-I\">g<\/span><\/span><span id=\"MJXc-Node-18\" class=\"mjx-texatom\"><span id=\"MJXc-Node-19\" class=\"mjx-mrow\"><span id=\"MJXc-Node-20\" class=\"mjx-mo\"><span class=\"mjx-char MJXc-TeX-main-R\">\/<\/span><\/span><\/span><\/span><span id=\"MJXc-Node-21\" class=\"mjx-mi\"><span class=\"mjx-char MJXc-TeX-math-I\">m<\/span><\/span><span id=\"MJXc-Node-22\" class=\"mjx-mi\"><span class=\"mjx-char MJXc-TeX-math-I\">L<\/span><\/span><\/span><\/span><span class=\"MJX_Assistive_MathML\" role=\"presentation\">1,000\u03bcg\/mL<\/span><\/span>\u00a0) of each extract at DPPH radical scavenging activities of SIE, PME and SBE were 10.5%, 5.5% and 86.8% respectively,\u00a0<span id=\"MathJax-Element-3-Frame\" class=\"mjx-chtml MathJax_CHTML\" style=\"box-sizing: border-box; display: inline-block; line-height: 0; text-indent: 0px; text-align: left; text-transform: none; font-style: normal; font-weight: normal; font-size: 21.7px; letter-spacing: normal; overflow-wrap: normal; word-spacing: normal; white-space: nowrap; float: none; direction: ltr; max-width: none; max-height: none; min-width: 0px; min-height: 0px; border: 0px; margin: 0px; padding: 1px 0px; position: relative;\" tabindex=\"0\" role=\"presentation\" data-mathml=\"&lt;math xmlns=&quot;http:\/\/www.w3.org\/1998\/Math\/MathML&quot;&gt;&lt;mi&gt;A&lt;\/mi&gt;&lt;mi&gt;B&lt;\/mi&gt;&lt;mi&gt;T&lt;\/mi&gt;&lt;msup&gt;&lt;mi&gt;S&lt;\/mi&gt;&lt;mo&gt;+&lt;\/mo&gt;&lt;\/msup&gt;&lt;\/math&gt;\"><span id=\"MJXc-Node-23\" class=\"mjx-math\" aria-hidden=\"true\"><span id=\"MJXc-Node-24\" class=\"mjx-mrow\"><span id=\"MJXc-Node-25\" class=\"mjx-mi\"><span class=\"mjx-char MJXc-TeX-math-I\">A<\/span><\/span><span id=\"MJXc-Node-26\" class=\"mjx-mi\"><span class=\"mjx-char MJXc-TeX-math-I\">B<\/span><\/span><span id=\"MJXc-Node-27\" class=\"mjx-mi\"><span class=\"mjx-char MJXc-TeX-math-I\">T<\/span><\/span><span id=\"MJXc-Node-28\" class=\"mjx-msubsup\"><span class=\"mjx-base\"><span id=\"MJXc-Node-29\" class=\"mjx-mi\"><span class=\"mjx-char MJXc-TeX-math-I\">S<\/span><\/span><\/span><span class=\"mjx-sup\"><span id=\"MJXc-Node-30\" class=\"mjx-mo\"><span class=\"mjx-char MJXc-TeX-main-R\">+<\/span><\/span><\/span><\/span><\/span><\/span><span class=\"MJX_Assistive_MathML\" role=\"presentation\">ABTS+<\/span><\/span>\u00a0radical activities were 4.92%, 5.9% and 62.3% respectively, reducing powers (OD 700) were 0.15, 0.18 and 1.7 respectively, and SOD-like activities were 17.0%, 15.9% and 38.6% respectively.\u00a0In addition, SBE significantly decreased the cell viability of androgen-sensitive lymph node metastasis type of prostate cancer (LNCaP) cells in a dose-dependent manner.\u00a0Morphological study of SBE-treated LNCaP cells revealed distorted and shrunken cell masses.\u00a0SBE-induced cell death was confirmed by observation of nuclear condensation and increased formation of apoptotic bodies.\u00a0The antiproliferative effect of SBE seems to be associated with the antioxidant activity of its polyphenol content.\u00a0The results of this study indicate that SBE can exert antioxidant and antiproliferative effects and may be as a useful food material.<\/p>\n<p class=\"g-color-gray-dark-v2 text-justify\">In this paper, the antioxidant activity and inhibition of human prostate cancer cell growth were evaluated for the extracts of millet, millet and sorghum.\u00a0As a result of confirming the antioxidant activity of millet, millet and sorghum extracts through DPPH radical scavenging ability, ABTS radical scavenging ability, reducing power and SOD-like activity, a concentration-dependent increase in antioxidant activity was observed in the sorghum extract, which was showed higher efficacy.\u00a0As a result of confirming the cancer cell proliferation inhibitory activity using two different types of human prostate cancer cells (PC-3 and LNCaP), the treatment of crude extract and millet extract was\u00a0<span id=\"MathJax-Element-4-Frame\" class=\"mjx-chtml MathJax_CHTML\" style=\"box-sizing: border-box; display: inline-block; line-height: 0; text-indent: 0px; text-align: left; text-transform: none; font-style: normal; font-weight: normal; font-size: 21.7px; letter-spacing: normal; overflow-wrap: normal; word-spacing: normal; white-space: nowrap; float: none; direction: ltr; max-width: none; max-height: none; min-width: 0px; min-height: 0px; border: 0px; margin: 0px; padding: 1px 0px; position: relative;\" tabindex=\"0\" role=\"presentation\" data-mathml=\"&lt;math xmlns=&quot;http:\/\/www.w3.org\/1998\/Math\/MathML&quot;&gt;&lt;mn&gt;1&lt;\/mn&gt;&lt;mo&gt;,&lt;\/mo&gt;&lt;mn&gt;000&lt;\/mn&gt;&lt;mrow class=&quot;MJX-TeXAtom-ORD&quot;&gt;&lt;mi&gt;&amp;#x03BC;&lt;\/mi&gt;&lt;\/mrow&gt;&lt;mi&gt;g&lt;\/mi&gt;&lt;mrow class=&quot;MJX-TeXAtom-ORD&quot;&gt;&lt;mo&gt;\/&lt;\/mo&gt;&lt;\/mrow&gt;&lt;mi&gt;m&lt;\/mi&gt;&lt;mi&gt;L&lt;\/mi&gt;&lt;\/math&gt;\"><span id=\"MJXc-Node-31\" class=\"mjx-math\" aria-hidden=\"true\"><span id=\"MJXc-Node-32\" class=\"mjx-mrow\"><span id=\"MJXc-Node-33\" class=\"mjx-mn\"><span class=\"mjx-char MJXc-TeX-main-R\">One<\/span><\/span><span id=\"MJXc-Node-34\" class=\"mjx-mo\"><span class=\"mjx-char MJXc-TeX-main-R\">,<\/span><\/span><span id=\"MJXc-Node-35\" class=\"mjx-mn MJXc-space1\"><span class=\"mjx-char MJXc-TeX-main-R\">000<\/span><\/span><span id=\"MJXc-Node-36\" class=\"mjx-texatom\"><span id=\"MJXc-Node-37\" class=\"mjx-mrow\"><span id=\"MJXc-Node-38\" class=\"mjx-mi\"><span class=\"mjx-char MJXc-TeX-math-I\">\u03bc<\/span><\/span><\/span><\/span><span id=\"MJXc-Node-39\" class=\"mjx-mi\"><span class=\"mjx-char MJXc-TeX-math-I\">g<\/span><\/span><span id=\"MJXc-Node-40\" class=\"mjx-texatom\"><span id=\"MJXc-Node-41\" class=\"mjx-mrow\"><span id=\"MJXc-Node-42\" class=\"mjx-mo\"><span class=\"mjx-char MJXc-TeX-main-R\">\/<\/span><\/span><\/span><\/span><span id=\"MJXc-Node-43\" class=\"mjx-mi\"><span class=\"mjx-char MJXc-TeX-math-I\">m<\/span><\/span><span id=\"MJXc-Node-44\" class=\"mjx-mi\"><span class=\"mjx-char MJXc-TeX-math-I\">L<\/span><\/span><\/span><\/span><span class=\"MJX_Assistive_MathML\" role=\"presentation\">1,000\u03bcg\/mL<\/span><\/span>\u00a0Although no significant inhibitory effect could be confirmed even at the concentration of\u00a0<span id=\"MathJax-Element-5-Frame\" class=\"mjx-chtml MathJax_CHTML\" style=\"box-sizing: border-box; display: inline-block; line-height: 0; text-indent: 0px; text-align: left; text-transform: none; font-style: normal; font-weight: normal; font-size: 21.7px; letter-spacing: normal; overflow-wrap: normal; word-spacing: normal; white-space: nowrap; float: none; direction: ltr; max-width: none; max-height: none; min-width: 0px; min-height: 0px; border: 0px; margin: 0px; padding: 1px 0px; position: relative;\" tabindex=\"0\" role=\"presentation\" data-mathml=\"&lt;math xmlns=&quot;http:\/\/www.w3.org\/1998\/Math\/MathML&quot;&gt;&lt;mn&gt;10&lt;\/mn&gt;&lt;mrow class=&quot;MJX-TeXAtom-ORD&quot;&gt;&lt;mi&gt;&amp;#x03BC;&lt;\/mi&gt;&lt;\/mrow&gt;&lt;mi&gt;g&lt;\/mi&gt;&lt;mrow class=&quot;MJX-TeXAtom-ORD&quot;&gt;&lt;mo&gt;\/&lt;\/mo&gt;&lt;\/mrow&gt;&lt;mi&gt;m&lt;\/mi&gt;&lt;mi&gt;L&lt;\/mi&gt;&lt;\/math&gt;\"><span id=\"MJXc-Node-45\" class=\"mjx-math\" aria-hidden=\"true\"><span id=\"MJXc-Node-46\" class=\"mjx-mrow\"><span id=\"MJXc-Node-47\" class=\"mjx-mn\"><span class=\"mjx-char MJXc-TeX-main-R\">10<\/span><\/span><span id=\"MJXc-Node-48\" class=\"mjx-texatom\"><span id=\"MJXc-Node-49\" class=\"mjx-mrow\"><span id=\"MJXc-Node-50\" class=\"mjx-mi\"><span class=\"mjx-char MJXc-TeX-math-I\">\u03bc<\/span><\/span><\/span><\/span><span id=\"MJXc-Node-51\" class=\"mjx-mi\"><span class=\"mjx-char MJXc-TeX-math-I\">g<\/span><\/span><span id=\"MJXc-Node-52\" class=\"mjx-texatom\"><span id=\"MJXc-Node-53\" class=\"mjx-mrow\"><span id=\"MJXc-Node-54\" class=\"mjx-mo\"><span class=\"mjx-char MJXc-TeX-main-R\">\/<\/span><\/span><\/span><\/span><span id=\"MJXc-Node-55\" class=\"mjx-mi\"><span class=\"mjx-char MJXc-TeX-math-I\">m<\/span><\/span><span id=\"MJXc-Node-56\" class=\"mjx-mi\"><span class=\"mjx-char MJXc-TeX-math-I\">L<\/span><\/span><\/span><\/span><span class=\"MJX_Assistive_MathML\" role=\"presentation\">10\u03bcg\/mL<\/span><\/span>\u00a0A significant cell proliferation inhibitory effect was confirmed from the concentration of\u00a0As a result of examining the morphological changes of PC-3 and LNCaP cells, suspension, death, and proliferation inhibition were observed in the group treated with the sorghum extract, but the group treated with crude and millet extract at the same concentration maintained a cell morphology similar to that of the control group. and no specific cytotoxicity was observed.\u00a0In the observation of nuclear morphology through Hoechst staining, morphological changes related to apoptosis, such as condensation of apoptotic bodies, cells, and nuclei, were observed only in the sorghum extract, in contrast to the crude and millet extracts.\u00a0The total polyphenol contents of millet, millet, and sorghum extracts were 2.01, 1.71, and 29.10 mg GAE\/g, respectively, and it was confirmed that sorghum, which had the highest total polyphenol content, had excellent antioxidant and anticancer effects.\u00a0As a result, it was confirmed that sorghum, which had the highest polyphenol content among millet, millet, and sorghum extracts, showed excellent antioxidant activity and growth inhibitory effects on human prostate cancer cells. It is expected that it can be used as a material.<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<p><span style=\"font-size: 14px; color: #666666; font-family: 'Work Sans', Arial, sans-serif;\">In this study, we evaluated antioxidant and antiproliferating effects of Setaria italica extract (SIE), Panicum miliaceum<\/span><\/p>\n<p>extract (PME) and Sorghum bicolor extract (SBE). Antioxidant effects of these extracts were determined by assessing<br \/>\nDPPH radical scavenging activity, ABTS<br \/>\n\u00b7+<br \/>\nradical scavenging activity, reducing power and superoxide dismutase<br \/>\n(SOD)-like activity. From high concentrations (1,000 \u03bcg\/mL) of each extract at DPPH radical scavenging activities<br \/>\nof SIE, PME and SBE were 10.5%, 5.5% and 86.8% respectively, ABTS<br \/>\n+<br \/>\nradical activities were 4.92%, 5.9%<br \/>\nand 62.3% respectively, reducing powers (OD 700) were 0.15, 0.18 and 1.7 respectively, and SOD-like activities<br \/>\nwere 17.0%, 15.9% and 38.6% respectively. In addition, SBE significantly decreased the cell viability of<br \/>\nandrogen-sensitive lymph node metastasis type of prostate cancer (LNCaP) cells in a dose-dependent manner.<br \/>\nMorphological study of SBE-treated LNCaP cells revealed distorted and shrunken cell masses. SBE-induced cell<br \/>\ndeath was confirmed by observation of nuclear condensation and increased formation of apoptotic bodies. The<br \/>\nantiproliferative effect of SBE seems to be associated with the antioxidant activity of its polyphenol content. The<br \/>\nresults of this study indicate that SBE can exert antioxidant and antiproliferative effects and may be as a useful<br \/>\nfood material.<br \/>\nKey words\uff1aantioxidant, antiproliferating, Panicum miliaceum, Setaria italica, Sorghum bicolor<\/p>\n<p><a href=\"https:\/\/scholar.google.com\/scholar_url?url=https:\/\/www.koreascience.or.kr\/article\/JAKO201609633504282.pdf&amp;hl=en&amp;sa=X&amp;ei=_choY8-oLKmXy9YP-dmcqAM&amp;scisig=AAGBfm11JvFhyqmtGXXqKoTW_G7Ib1Q7vA&amp;oi=scholarr\">https:\/\/scholar.google.com\/scholar_url?url=https:\/\/www.koreascience.or.kr\/article\/JAKO201609633504282.pdf&amp;hl=en&amp;sa=X&amp;ei=_choY8-oLKmXy9YP-dmcqAM&amp;scisig=AAGBfm11JvFhyqmtGXXqKoTW_G7Ib1Q7vA&amp;oi=scholarr<\/a><\/p>\n<p>&nbsp;<\/p>\n<p><a href=\"https:\/\/scholar.google.com\/scholar?q=sorghum+bicolor+polyphenols+and+Prostate+cancer&amp;hl=en&amp;as_sdt=0&amp;as_vis=1&amp;oi=scholart\">https:\/\/scholar.google.com\/scholar?q=sorghum+bicolor+polyphenols+and+Prostate+cancer&amp;hl=en&amp;as_sdt=0&amp;as_vis=1&amp;oi=scholart<\/a><\/p>\n<p>&nbsp;<\/p>\n<p>Sorghum Extract Enhances Caspase-dependent Apoptosis in Primary Prostate<br \/>\nCancer Cells and Immune Activity in Macrophages<br \/>\nHyun-Dong Cho1<br \/>\n, Jeong-Ho Kim2<br \/>\n, Seong-Min Hong3<br \/>\n, Ju-Hye Lee4<br \/>\n, Du-Hyun Kim5<br \/>\nand Kwon-Il Seo3<br \/>\n*<br \/>\n1<br \/>\nDepartment of Food Science and Technology, Kyungpook National University, Daegu 41566, Korea 2<br \/>\nDepartment of Food and Nutrition, Sunchon National University, Suncheon 57922, Korea 3<br \/>\nDepartment of Biotechnology, Dong-A University, Busan 49315, Korea 4<br \/>\nFunctional Food and Nutrition Division, Department of Agro-Food Resource, National Academy of Agricultural Science, Rural Development<br \/>\nAdministration, Wanju 565-871, Korea<br \/>\n5<br \/>\nDepartment of Life Resources Industry, Dong-A University, Busan 49315, Korea<br \/>\nReceived November 8, 2016 \/Revised November 30, 2016 \/Accepted December 6, 2016<br \/>\nSorghum bicolor L. is one of the important minor cereals in Asia, Africa, and the central United States,<br \/>\nand it is considered a rich source of polyphenols, flavonoids, and dietary fiber. However, there is a<br \/>\nlack of data on the anti-cancer activity of Sorghum in prostate cancer cells and immune activity in<br \/>\nmacrophages. This study aims to investigate the potential effects of an ethanol extract of S. bicolor L.<br \/>\n(SE) on inducing apoptosis in RC-58T\/h\/SA#4 cells and immunomodulatory activity in RAW 264.7<br \/>\ncells. SE significantly inhibited the viability of RC-58T\/h\/SA#4 primary prostate cancer cells in a<br \/>\ndose-dependent manner. The morphology of RC-58T\/h\/SA#4 cells treated with SE was shrunken and<br \/>\ninvolved the formation of an apoptotic body and nuclear condensation. In addition, SE markedly acti-<br \/>\nvated caspase-8, -9, and -3; increased the protein levels of Bax, p53, cleaved PARP, and cytosolic cyto-<br \/>\nchrome c; and decreased Bcl-2 protein expression. Furthermore, the inhibition of caspases in RC-58T\/<br \/>\nh\/SA#4 cells with z-VAD-fmk attenuated SE-induced cell growth inhibition. The production of nitric<br \/>\noxide (NO) was also elevated by SE treatment, as revealed by immune response parameters. These<br \/>\nresults suggest that SE inhibits growth and induces apoptosis in primary human prostate cancer cells<br \/>\nin a caspase-dependent manner, and it modulates the immune functions in macrophages. Therefore,<br \/>\nSorghum bicolor L. may be used as a functional food to prevent prostate cancer and enhance immune<br \/>\nactivity.<br \/>\nKey words : Apoptosis, immune activity, RC-58T\/h\/SA#4, Sorghum ethanol extract<\/p>\n","protected":false},"excerpt":{"rendered":"<p>&nbsp; Login English Korea\u00a0Science &nbsp; &nbsp; Korean Journal of Food\u00a0Preservation Volume 23 Issue 7 \/ Pages.1033-1041 \/ 2016 \/ 1738-7248 (pISSN) \/ 2287-7428 (eISSN) The Korean Society of Food Preservation Antioxidant and antiproliferating effects of Setaria italica, Panicum miliaceum and Sorghum bicolor extracts on prostate cancer cell lines Antioxidant effect and inhibition of prostate cancer&hellip;<\/p>\n","protected":false},"author":93,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-7795","post","type-post","status-publish","format-standard","hentry","category-uncategorized"],"_links":{"self":[{"href":"https:\/\/jobelyn.com.ng\/ng\/wp-json\/wp\/v2\/posts\/7795","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/jobelyn.com.ng\/ng\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/jobelyn.com.ng\/ng\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/jobelyn.com.ng\/ng\/wp-json\/wp\/v2\/users\/93"}],"replies":[{"embeddable":true,"href":"https:\/\/jobelyn.com.ng\/ng\/wp-json\/wp\/v2\/comments?post=7795"}],"version-history":[{"count":4,"href":"https:\/\/jobelyn.com.ng\/ng\/wp-json\/wp\/v2\/posts\/7795\/revisions"}],"predecessor-version":[{"id":7801,"href":"https:\/\/jobelyn.com.ng\/ng\/wp-json\/wp\/v2\/posts\/7795\/revisions\/7801"}],"wp:attachment":[{"href":"https:\/\/jobelyn.com.ng\/ng\/wp-json\/wp\/v2\/media?parent=7795"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/jobelyn.com.ng\/ng\/wp-json\/wp\/v2\/categories?post=7795"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/jobelyn.com.ng\/ng\/wp-json\/wp\/v2\/tags?post=7795"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}