IMMUNITY MODULATION

SORGHUM BICOLOR

Sorghum bicolor is a species of grass, traditionally cultivated for its nutritious grain. Sorghum is now grown in many tropical and subtropical regions of the world, and is gaining increased popularity as a non-gluten grain. Historical uses of Sorghum include food, hot teas, beers, and traditional medicinal extracts.

Health benefits include

  • Multi-facetted anti-inflammatory properties
  • Immune activation
  • Hematopoietic effect
  • Pain reduction

WEST AFRICAN SORGHUM-BASED JOBELYNTM HAS IMMUE ACTIVATING PROPERTIES IN LABORATORY TESTS

JobelynTM is produced from a unique variety of Sorghum bicolor, recently domesticated from a West African wild variety, representing original genetic makeup and not a result of intense breeding efforts. Jobelyn TM is an extract derived specifically from the intensely colored leaf sheathes. JobelynTM is GRAS-certified by the FDA. JobelynTM has an unusual chemical profile compared to other variants of Sorghum bicolor. It has a very high content of unique antioxidant polyphenols, including unique dimeric 3-deoxyanthocyanidins. Given the traditional use of Sorghum-based products, including teas, in prevention of viral illness, JobelynTM was tested for immune activating properties in laboratory tests.

Our immune system is not limited to a given organ or tissue, but is widespread throughout our body, blood, skin, and mucosal barriers. Immune cells, when activated, communicate in various ways by:

  • Expressing receptors on cell surfaces to receive signals.
  • Secreting compounds to send signals to other cells.

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Jobelyn TM treatment of human immune cells resulted in increased expression of the CD69 activation marker on the cell surface of Natural Killer cells, NKT cells, T lymphocytes, and monocytes. The cytokine profile in these cell cultures showed up-regulation of multiple cytokines, including several chemokines known to be involved in anti-viral immune defenses.