Sorghum bicolor leaf sheath (Jobelyn), with potential antioxidant, anti-inflammatory, chemopreventive and immunomodulating activities

In a recent web publication, the NATIONAL CANCER INSTITUTE announced that Sorghum bicolor leaf sheath (Jobelyn), has been listed in their dictionary of drugs.

Sorghum bicolor supplement

The National Institute of Cancer defined Sorghum bicolor leaf sheath (Jobelyn) as
An herbal-based nutritional supplement containing the leaf sheaths of the plant Sorghum bicolor, with potential antioxidant, anti-inflammatory, chemopreventive and immunomodulating activities. Sorghum bicolor supplement contains various phytochemicals, including phenolic acids and polyphenols such as proanthocyanidins. Sorghum bicolor supplement is particularly rich in 3-deoxyanthocyanins, such as luteolinidin and apigeninidin, and appears to induce apoptosis and inhibit cell proliferation in cancer cells through the stimulation of various apoptosis promoter genes and the downregulation of certain apoptosis inhibitor genes. In addition, due to the strong antioxidant nature of the phytochemicals, these compounds are able to scavenge free radicals and prevent tissue damage. Also, intake of this supplement modulates the immune system by both increasing the activity of natural killer (NK) cells and initiating the activation of macrophages.
Synonym: sorghum bicolor extract
Foreign brand name: Jobelyn

The emphasis in this description is that phenolic acids and polyphenols are responsible for its antioxidant, anti-inflammatory, chemopreventive and immuno-modulating activities.

What are polyphenols?

Polyphenols, organic compounds found abundantly in plants, have become an emerging field of interest in nutrition in recent decades. A growing body of research indicates that polyphenol consumption may play a vital role in health through the regulation of metabolism, weight, chronic disease, and cell proliferation. Over 8,000 polyphenols have thus far been identified, though their short- and long-term health effects have not been fully characterized. Animal, human and epidemiologic studies show that various polyphenols have antioxidant and anti-inflammatory properties that could have preventive and/or therapeutic effects for cardiovascular disease, neurodegenerative disorders, cancer, and obesity. However, some have cautioned that there may be harmful effects of overconsumption, especially in cases where compounds are isolated rather than consumed in a food matrix.

Popular sources of polyphenols

Polyphenols Supplements

Polyphenol supplements usually provide either a variety of broad-spectrum polyphenols sourced from superfoods, berries and herbs or contain high-purity, high-potency extracts. The best polyphenol supplements include ingredients sourced from resveratrol-containing foods, elderberries, bilberries, cranberries, green tea extract, quercetin, turmeric, bitter orange, and chokeberries.

Polyphenols in JOBELYN for Health Forever Product Limited

Sample ID Brunswick ORAChydro* ORAClipo ^ ORACtotal Phenolics
Lab ID (mmoleTE/g) (mmoleTE/g) (mmoleTE/g) (mg/g)
Jobelyn Leaf Sheath Powder  06-4111 2,511 261 2,772 106.35
Jobelyn Leaf Sheath Powder  06-3017 3,123 3,123  106.86
Jobelyn Leaf Sheath Powder 06-4812  1,877 199  2,076 100.72
Jobelyn Leaf Sheath Powder 06-4813   1,677 161  1,838 93.80

 

The phenolic result is expressed as milligram gallic acid equivalent per gram*The ORAC analysis provides a measure of the scavenging capacity of antioxidants against the peroxyl radical, which is one of the most common reactive oxygen species (ROS) found in the body. ORAChydro reflects water-soluble antioxidant capacity and the ^ ORAClipo is the lipid soluble antioxidant capacity. Trolox, a water-soluble Vitamin E analog, is used as the calibration standard and the ORAC result is expressed as micromole Trolox equivalent (TE) per gram.

The acceptable precision of the ORAC assay is 15% relative standard deviation.1-2

1 Ou, B; Hampsch-Woodill, M.; Prior, R. L.; Development and Validation of an Improved Oxygen Radical Absorbance Capacity Assay using Fluorescein as the Fluorescent Probe. Journal of Agricultural and Food Chemistry.; 2001; 49(10); 4619-4626

2 Huang, D.; Ou, B.; Hampsch-Woodill, M.; Flanagan, J.; Deemer, E. K.; Development and Validation of Oxygen Radical Absorbance Capacity Assay for Lipophilic Antioxidants using Randomly Methylated –Cyclodextrin as the Solubility Enhancer. Journal of Agricultural and Food Chemistry.; 2002, 50(7); 1815-1821.

QC TABLE OF COMPOUNDS IN SAMPLE

Lot No BL ID No. Conc. (µg/g)
Apigeninidin Luteolinindin Apigenin Luteolin Naringenin
12-2003 06-4107 14,650 216 3,695 530 151
12-2005 06-4108 23,950 328 5,100 715 244
12-2006 RAT 1:5 06-4109 22,950 229 3,770 396 90.0
12-2006 RAT 1:10 06-4110 27,650 286 4,770 570 122
12-2006 RAT 1:20 06-4111 31,900 331 5,300 640 149
12-2006 New Pot 06-4112 21,850 168 2,975 218 71.0
12-2005 RAT 1:20 06-4812 38,650 323 6,020 585 230
12-2006 RAT 1:50 06-4813 29,850 170 4,050 339 118

 

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