Apigeninidin-rich Sorghum bicolor (L. Moench) extracts suppress A549 cells proliferation and ameliorate toxicity of aflatoxin B1-mediated liver and kidney derangement in rats

Apigeninidin-rich Sorghum bicolor (L. Moench) extracts suppress A549 cells proliferation and ameliorate toxicity of aflatoxin B1-mediated liver and kidney derangement in rats_

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Since S. bicolor sheaths contain active principles with antioxidant, anti-inflammatory and chemo-preventive activities, we hypothesise that our extracts are more likely to alleviate the toxic effects of AFB₁ in the rat model. We considered the AFB₁ model of toxicity because it has been reported that AFB₁ exposure orchestrates hepatocellular carcinoma⁹⁵ and lung adenocarcinoma in humans⁹⁶, thus making it a public health issue globally^97,98.