Diabetes Mellitus (DM) and Alzheimer’s disease (AD) are two prevalent diseases in modern societies, which are caused mainly by current lifestyle, aging and genetic alterations. It has already been demonstrated that these two diseases are associated, since individuals suffering from DM are prone to develop AD. Conversely, it is also known that individuals with AD are more susceptible to DM, namely type 2 diabetes (T2DM). Therefore, these two pathologies, although completely different in terms of symptomatology, end up sharing several mechanisms at the molecular level, with the most obvious be-ing the increase of oxidative stress and inflammation.
Polyphenols are natural compounds widely spread in fruits and vegetables whose dietary intake has been considerably proportional to the incidence of DM and AD. So, it is believed that this group of phytochemicals may have preventive and therapeutic potential, not only by reducing the risk and delaying the development of these pathologies, but also by improving brain’s metabolic profile and cognitive function
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6712293/
Recently, Sorghum bicolor supplement was listed in the drug dictionary of the National Cancer Institute and described described as being rich in Polyphenols and phenolic compounds with the potential for antioxidant,anti-inflammatory, immunomodulating and chemopreventive capabilities
https://www.cancer.gov/publications/dictionaries/cancer-drug/def/sorghum-bicolor-supplement
In an animal model, the scientists from the University of Ibadan led by Professor Umukoro demonstrated that that Sorghum bicolor
Jobelyn has anti-amnesic activity and might offer some promising effects for the treatment of memory deficits. Although more studies are necessary, the present data suggest that the anti-amnesic property of Sorghum bicolor supplement Jobelyn appears to be mediated through the scavenging of reactive oxygen species and/or inhibition of their formation.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4202556/
Sorghum extract exerts an anti-diabetic effect by improving insulin sensitivity via PPAR-γ in mice fed a high-fat diet
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3439576/
Network pharmacology of bioactives from Sorghum bicolor with targets related to diabetes mellitus
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7774932/
- Preadministration of Fermented Sorghum Diet Provides Protection against Hyperglycemia-Induced Oxidative Stress and Suppressed Glucose Utilization in Alloxan-Induced Diabetic Rats
https://www.frontiersin.org/articles/10.3389/fnut.2018.00016/full
http://www.eurekaselect.com/article/95778
Sorghum (Sorghum bicolor) Extract Affects Plasma Lipid Metabolism and Hepatic Macrophage Infiltration in Diabetic Rats
http://www.eurekaselect.com/article/95778
Anti-diabetic effect of sorghum extract on hepatic gluconeogenesis of streptozotocin-induced diabetic rats
https://nutritionandmetabolism.biomedcentral.com/articles/10.1186/1743-7075-9-106
Grain sorghum muffin reduces glucose and insulin responses in men
https://pubs.rsc.org/en/content/articlehtml/2014/fo/c3fo60432b
THE POTENTIAL OF SORGHUM BICOLOR L. AS A BLOOD GLUCOSE LOWERING AGENT : A REVIEW
https://journal.uin-alauddin.ac.id/index.php/kesehatan/article/view/18181
Sorghum halepense (L.) Pers rhizomes inhibitory potential against diabetes and free radicals
https://clinphytoscience.springeropen.com/articles/10.1186/s40816-021-00259-3
