Prostate cancer is the second most common cancer in males. The side effects of convention antineoplastic drugs and sustained risks of recurrence and metastasis necessitate the search for safer chemopreventive and chemotherapeutic drugs. The cereal grain sorghum contains various polyphenols with potent anti-cancer and antioxidant activities. To evaluate the anti-tumor efficacy of Donganme sorghum ethyl-acetate extract (DSEE), we performed content analysis and evaluated its effects on PC3M prostate cancer cell proliferation, cell cycle progression, and migration in vitro, and on PC3M orthotopic tumor growth in vivo. DSEE decreased viable cell number in a dose-dependent manner, increased apoptosis rate by activating the intrinsic apoptosis pathway, induced cell cycle arrest at G0 by reducing cyclin expression, suppressed cell migration and expression of matrix metalloproteinase-2 and -9. Moreover, DSEE inhibited orthotopic tumor growth and metastasis in mice. Therefore, DSEE may have potential preventive and therapeutic efficacy against prostate cancer.
https://www.sciencedirect.com/science/article/abs/pii/S1756464617304516#:~:text=These%20effects%20of%20DSEE%20on,dietary%20supplements%20against%20prostate%20cancer.https://www.sciencedirect.com/science/article/abs/pii/S1756464617304516#:~:text=These%20effects%20of%20DSEE%20on,dietary%20supplements%20against%20prostate%20cancer.
Prostate cancer is the most prevalent disease affecting males in many Western countries, with an estimated 29,480 deaths in 2014 in the US alone. Incidence rates for prostate cancer deaths have been decreasing since the early 1990s in men of all races/ethnicities, though they remain about 60% higher in African Americans than in any other group. The relationship between dietary polyphenols and the prevention of prostate cancer has been examined previously. Although results are sometimes inconsistent and variable, there is a general agreement that polyphenols hold great promise for the future management of prostate cancer. Various dietary components, including polyphenols, have been shown to possess anti-cancer properties. Generally considered as non-toxic, dietary polyphenols act as key modulators of signaling pathways and are therefore considered ideal chemopreventive agents. Besides possessing various anti-tumor properties, dietary polyphenols also contribute to epigenetic changes associated with the fate of cancer cells and have emerged as potential drugs for therapeutic intervention. Polyphenols have also been shown to affect post-translational modifications and microRNA expressions. This article provides a systematic review of the health benefits of selected dietary polyphenols in prostate cancer, especially focusing on the subclasses of polyphenols, which have a great effect on disease prevention and treatment.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4346900/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4346900/
Sorghum bicolor Supplement is listed in the drug dictionary of the National Cancer Institute and described as being rich in Polyphenols and phenolic acids with the potential for antioxidant, anti-inflammatory, immunomodulating and chemopreventive capabilities.
https://www.cancer.gov/publications/dictionaries/cancer-drug/def/sorghum-bicolor-supplement
https://www.cancer.gov/publications/dictionaries/cancer-drug/def/sorghum-bicolor-supplement
