In a recent web publication, the NATIONAL CANCER INSTITUTE announced that Sorghum bicolor leaf sheath (Jobelyn), has been listed in their dictionary of drugs.
Sorghum bicolor supplement
Synonym: | sorghum bicolor extract |
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Foreign brand name: | Jobelyn |
The emphasis in this description is that phenolic acids and polyphenols are responsible for its antioxidant, anti-inflammatory, chemopreventive and immuno-modulating activities.
What are polyphenols?
Polyphenols, organic compounds found abundantly in plants, have become an emerging field of interest in nutrition in recent decades. A growing body of research indicates that polyphenol consumption may play a vital role in health through the regulation of metabolism, weight, chronic disease, and cell proliferation. Over 8,000 polyphenols have thus far been identified, though their short- and long-term health effects have not been fully characterized. Animal, human and epidemiologic studies show that various polyphenols have antioxidant and anti-inflammatory properties that could have preventive and/or therapeutic effects for cardiovascular disease, neurodegenerative disorders, cancer, and obesity. However, some have cautioned that there may be harmful effects of overconsumption, especially in cases where compounds are isolated rather than consumed in a food matrix.
Popular sources of polyphenols
Polyphenols Supplements
Polyphenol supplements usually provide either a variety of broad-spectrum polyphenols sourced from superfoods, berries and herbs or contain high-purity, high-potency extracts. The best polyphenol supplements include ingredients sourced from resveratrol-containing foods, elderberries, bilberries, cranberries, green tea extract, quercetin, turmeric, bitter orange, and chokeberries.
Polyphenols in JOBELYN for Health Forever Product Limited
Sample ID | Brunswick | ORAChydro* | ORAClipo ^ | ORACtotal | Phenolics |
Lab ID | (mmoleTE/g) | (mmoleTE/g) | (mmoleTE/g) | (mg/g) | |
Jobelyn Leaf Sheath Powder | 06-4111 | 2,511 | 261 | 2,772 | 106.35 |
Jobelyn Leaf Sheath Powder | 06-3017 | 3,123 | 3,123 | 106.86 | |
Jobelyn Leaf Sheath Powder | 06-4812 | 1,877 | 199 | 2,076 | 100.72 |
Jobelyn Leaf Sheath Powder | 06-4813 | 1,677 | 161 | 1,838 | 93.80 |
The phenolic result is expressed as milligram gallic acid equivalent per gram*The ORAC analysis provides a measure of the scavenging capacity of antioxidants against the peroxyl radical, which is one of the most common reactive oxygen species (ROS) found in the body. ORAChydro reflects water-soluble antioxidant capacity and the ^ ORAClipo is the lipid soluble antioxidant capacity. Trolox, a water-soluble Vitamin E analog, is used as the calibration standard and the ORAC result is expressed as micromole Trolox equivalent (TE) per gram.
The acceptable precision of the ORAC assay is 15% relative standard deviation.1-2
1 Ou, B; Hampsch-Woodill, M.; Prior, R. L.; Development and Validation of an Improved Oxygen Radical Absorbance Capacity Assay using Fluorescein as the Fluorescent Probe. Journal of Agricultural and Food Chemistry.; 2001; 49(10); 4619-4626
2 Huang, D.; Ou, B.; Hampsch-Woodill, M.; Flanagan, J.; Deemer, E. K.; Development and Validation of Oxygen Radical Absorbance Capacity Assay for Lipophilic Antioxidants using Randomly Methylated –Cyclodextrin as the Solubility Enhancer. Journal of Agricultural and Food Chemistry.; 2002, 50(7); 1815-1821.
QC TABLE OF COMPOUNDS IN SAMPLE
Lot No | BL ID No. | Conc. (µg/g) | ||||
Apigeninidin | Luteolinindin | Apigenin | Luteolin | Naringenin | ||
12-2003 | 06-4107 | 14,650 | 216 | 3,695 | 530 | 151 |
12-2005 | 06-4108 | 23,950 | 328 | 5,100 | 715 | 244 |
12-2006 RAT 1:5 | 06-4109 | 22,950 | 229 | 3,770 | 396 | 90.0 |
12-2006 RAT 1:10 | 06-4110 | 27,650 | 286 | 4,770 | 570 | 122 |
12-2006 RAT 1:20 | 06-4111 | 31,900 | 331 | 5,300 | 640 | 149 |
12-2006 New Pot | 06-4112 | 21,850 | 168 | 2,975 | 218 | 71.0 |
12-2005 RAT 1:20 | 06-4812 | 38,650 | 323 | 6,020 | 585 | 230 |
12-2006 RAT 1:50 | 06-4813 | 29,850 | 170 | 4,050 | 339 | 118 |